C23, an eCIRP inhibitor, was given 1 h prior to induction of AP. C57BL/6 mice underwent retrograde infusion of taurocholate into the pancreatic duct. In the present study, we studied the role of extracellular cold-inducible RNA-binding protein (eCIRP), a novel damage-associated-molecular-pattern molecule, in severe AP. Neutrophil extracellular traps (NETs) play a key role in the development of acute pancreatitis (AP).
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